{"id":12906,"date":"2022-03-30T13:03:26","date_gmt":"2022-03-30T12:03:26","guid":{"rendered":"https:\/\/library.biobridge-event.com\/knowledge\/?p=12906"},"modified":"2022-03-30T13:42:08","modified_gmt":"2022-03-30T12:42:08","slug":"newsletter-10-march-2022","status":"publish","type":"post","link":"https:\/\/library.biobridge-event.com\/knowledge\/2022\/03\/30\/newsletter-10-march-2022\/","title":{"rendered":"Newsletter #10 March 2022"},"content":{"rendered":"\n\n\n
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Each month, find new publications about regenerative medicine<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/td>\n

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Issue #10, March 2022<\/strong><\/span><\/span><\/h2>\n

AAD 2022 Special Issue<\/span><\/span><\/h4>\n

Biobridge Foundation, Regenerative Medicine News<\/p>\n

Androgenetic alopecia (AGA) is a common chronic hair loss disorder. It affects up to 80% Caucasian men and 40% women. Although AGA is highly prevalent, approved therapeutic options are limited, with potential adverse effects. Platelet-rich plasma (PRP) is an emerging treatment for AGA. The regenerative potential of PRP depends on the growth factors (GF) released by platelets. GF appear to act in the bulge area, activating the proliferative phase of the hair. Therefore, PRP is a potential treatment of AGA.
\nAlthough there were several systemic reviews and meta-analyses on the application of PRP in the treatment of AGA1,2<\/sup> , the work presented below, stands out because it focuses on female patients.<\/span><\/span><\/span><\/span><\/p>\n

This newsletter contains recent publications and information on research and treatments using PRP or BMC concentrate.<\/span><\/span><\/span><\/span><\/p>\n

Bruno BOEZENNEC, MD, Managing Editor<\/em><\/span><\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
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Latest publication: Study – Female Androgenetic Alopecia<\/strong><\/span><\/h6>\n

Platelet-Rich Plasma in Female Androgenetic Alopecia: A Comprehensive Systematic Review and Meta-Analysis<\/strong><\/span><\/p>\n

In this work, Zhou et al.<\/i>3<\/sup> summarize different treatment regimes in female androgenetic alopecia (AGA), and quantitively analyze the efficacy of PRP in this disease.<\/p>\n

They evaluated 636 studies and 12 trials from six databases (MEDLINE, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials, LILACS, and CNKI ). Meta-analysis was conducted with enrolled observational studies and randomized controlled trials separately.<\/p>\n

A total of 42 studies (including 6 studies using Regen Lab technology4-9<\/sup>) including 776 female participants, covering 16 randomized controlled trials and 26 observational trials, were included for these systematic review and meta-analysis . PRP showed positive efficacy in treating female AGA in hair density compared to the control groups with odds ratio (OR) 1.61 [95% CI 0.52\u20132.70] and compared to baseline with OR 1.11 [95% CI 0.86\u20131.37].<\/p>\n

This work demonstrated an effective response and safety for the application of PRP in the treatment of female AGA. Especially for those patients with negative response to the topical use of minoxidil, PRP offers an alternative treatment option.<\/p>\n

The authors only used hair density as an endpoint to perform meta-analysis for the diversity of endpoint settings among the enrolled studies, while hair density is the most used one. This result is in accordance with previous systemic review.
\nTaken together, these results confirm the efficacy of PRP in the treatment of female AGA.<\/p>\n

1.Torabi P, Behrangi E, Goodarzi A, Rohaninasab M. A systematic review of the effect of platelet-rich plasma on androgenetic alopecia of women. Dermatol Ther. 2020 Nov;33(6):e13835. doi: 10.1111\/dth.13835. Epub 2020 Jul 31. PMID: 32588941.<\/span><\/a><\/p>\n

2.Evans AG, Mwangi JM, Pope RW, Ivanic MG, Botros MA, Glassman GE, Pearce FB Jr, Kassis S. Platelet-rich plasma as a therapy for androgenic alopecia: a systematic review and meta-analysis. J Dermatolog Treat. 2022 Feb;33(1):498-511. doi: 10.1080\/09546634.2020.1770171. Epub 2020 May 26. PMID: 32410524.<\/span><\/a><\/p>\n

3.Zhou S, Qi F, Gong Y, Zhang C, Zhao S, Yang X, He Y. Platelet-Rich Plasma in Female Androgenic Alopecia: A Comprehensive Systematic Review and Meta-Analysis. Front Pharmacol. 2021 May 6;12:642980.<\/span><\/a><\/p>\n

4.Gentile P, Garcovich S. Autologous activated platelet-rich plasma (AA-PRP) and non-activated (A-PRP) in hair growth: a retrospective, blinded, randomized evaluation in androgenetic alopecia. Expert Opin Biol Ther. 2020 Mar;20(3):327-337.<\/span><\/a><\/p>\n

5.Gkini MA, Kouskoukis AE, Tripsianis G, Rigopoulos D, Kouskoukis K. Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period. J Cutan Aesthet Surg. 2014 Oct-Dec;7(4):213-9.<\/span><\/a><\/p>\n

6.Shapiro J, Ho A, Sukhdeo K, Yin L, Lo Sicco K. Evaluation of platelet-rich plasma as a treatment for androgenetic alopecia: A randomized controlled trial. J Am Acad Dermatol. 2020 Nov;83(5):1298-1303.<\/span><\/a><\/p>\n

7.Juhasz MLW, Sukhdeo K, Lo Sicco K, Shapiro J. Stratifying clinical response to adjuvant platelet-rich plasma in patients with androgenetic alopecia. Br J Dermatol. 2020 Sep;183(3):580-582.<\/span><\/a><\/p>\n

8.Rossano F, Di Martino S, Iodice L, Di Paolo M, Misso S, Tomeo R, Marini AM, Brugnone R, Marlino S, Santorelli A, Di Francia R. Correlation between individual inflammation genetic profile and platelet rich plasma efficacy in hair follicle regeneration: a pilot study reveals prognostic value of IL-1a polymorphism. Eur Rev Med Pharmacol Sci. 2017 Nov;21(22):5247-5257.<\/span><\/a><\/p>\n

9.Ho A, Sukhdeo K, Lo Sicco K, Shapiro J. Trichologic response of platelet-rich plasma in androgenetic alopecia is maintained during combination therapy. J Am Acad Dermatol. 2020 Feb;82(2):478-479.<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
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RegenLab<\/span><\/a>\u00ae<\/sup>\u00a0is a leading innovator of medical devices for the preparation of platelet rich plasma (PRP). RegenLab develops, provides expertly designed and patented medical devices for PRP preparations, CE certified by European Notify body, approved by most national agencies worldwide. <\/span><\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
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New Medical Devices Regulation<\/span><\/h6>\n

The new Medical Devices Regulation (2017\/745\/EU), applicable since May 2021 in EU, will replace the existing Medical Devices Directives (93\/42\/EEC).<\/span><\/p>\n

This regulation provides a framework for the manufacture, modification, and use of devices when equivalent devices are not commercially available (Article 5 of the Medical Device Regulation). In these situations, health care facilities will be required to have appropriate quality management systems in place, to document the manufacturing process, design, and performance data of the devices, including their intended purpose, and to monitor experience gained from the clinical use of these devices.<\/p>\n

In the case of marketed devices, the manufacturer is responsible for the quality and safety of the product.<\/p>\n

Regen Lab actively pursues patent protection and regulatory approval of its products so that physicians have peace of mind that they can offer continuous, consistent, safe and effective treatment for their patients without the fear of being restricted in their practice.<\/p>\n

More info about Medical Devices Regulation<\/span><\/a><\/p>\n

More info about Regen Lab medical devices<\/span><\/a>\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
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These 3 books are intended for physicians who practice and conduct research in disciplines where PRP represents a therapeutic option as well as anyone seeking reliable and up-to-date information on this technology.<\/span><\/h6>\n
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Platelet-Rich Plasma (PRP) Standardization & Cell TherapyThis book<\/b> (178 pages, English) was written to help professionals involved in regenerative medicine to better understand PRP and cell therapies use. <\/span>Order it\u00a0<\/span><\/a><\/span><\/span>Standardized Platelet-Rich Plasma for Musculoskeletal Disorders<\/b> Based on 20 years of experience, this book (179 pages, English) was written to help professionals involved in the management of patients suffering from musculoskeletal disorders to better understand PRP and its combination with hyaluronic acid. <\/span>Order it<\/span><\/a><\/p>\n

RegenPRP\u00ae: Standardized Platelet Rich Plasma for Skin, Hair & Genitourinary Disorders\u00a0<\/b>Based on 20 years of experience, this book (211 pages, English) was written to help professionals involved in regenerative medicine for management of patients suffering from skin, hair and genitourinary disorders to better understand the use of PRP. <\/span>Order it<\/span><\/a><\/p>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n

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Live talks on specific therapeutic indications with international specialists<\/b>
\nThe Biobridge Foundation hosts a program of webinars, focused on various therapeutic areas within regenerative medicine, presented by international specialists. <\/span>Check out the full program<\/span><\/a><\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
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