{"id":12898,"date":"2022-03-30T12:40:17","date_gmt":"2022-03-30T11:40:17","guid":{"rendered":"https:\/\/library.biobridge-event.com\/knowledge\/?p=12898"},"modified":"2022-03-30T13:06:03","modified_gmt":"2022-03-30T12:06:03","slug":"newsletter-9-march-2022","status":"publish","type":"post","link":"https:\/\/library.biobridge-event.com\/knowledge\/2022\/03\/30\/newsletter-9-march-2022\/","title":{"rendered":"Newsletter #9 March 2022"},"content":{"rendered":"\n\n\n
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Each month, find new publications about regenerative medicine<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/td>\n

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Issue #9, March 2022<\/strong><\/span><\/span><\/h2>\n

Biobridge Foundation, Regenerative Medicine News<\/span><\/span><\/h4>\n

Orthobiology refers to the use of biological materials, such as bone marrow concentrate (BMC) and platelet-rich plasma (PRP) to promote regeneration of musculoskeletal tissues. In the article presented below, Vorobyov et a<\/i>l. describe the use of bone grafting combining allogeneic cancellous implants and autologous PRP to treat a bone defect. This work confirms the results of Scaglione et al. (2013)<\/i> who treated long bone nonunions with BMC (Prepared with RegenKit\u00ae<\/sup> Extracell BMC) combined with dried bone allograft,and those of\u00a0Lychagin et al. (2020)<\/i> which used intraosseous injections of platelet-rich plasma (Prepared with RegenACR\u00ae<\/sup>) to treat knee bone marrow lesions associated with osteoarthristis.<\/span><\/span><\/span><\/span><\/p>\n

This newsletter contains recent publications and information on research and treatments using PRP or BMC concentrate.<\/p>\n

Bruno BOEZENNEC, MD, Managing Editor<\/em><\/span><\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
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Latest publication: Study – Orthopedic surgery<\/strong><\/span><\/h6>\n

Autologous regenerative stimulants for bone allograft implantation<\/strong><\/span><\/p>\n

In their report, Vorobyov et al.<\/i>\u00a0present a clinical case where a combination of allogeneic osteoplastic materials with autologous platelet-rich plasma is used to reconstruct a cavity defect in the tibia.<\/p>\n

Firstly, the authors describe the basic principles of orthobiology and the different surgical techniques for bone reconstruction using bone transplantation, allogeneic bone material, autologous bone marrow cell concentrate, and autologous platelet-rich plasma (a-PRP).<\/p>\n

Then, they present the case of a young adult suffering from a cyst of the proximal central-medial metaphysis of the right tibia for which it was decided to carry out a bone grafting with allogeneic cancellous implants impregnated with activated a-PRP prepared with RegenKit\u00ae<\/sup> BCT \u00a0and RegenKit\u00ae<\/sup> ATS (Regen Lab SA, Switzerland). Activated a-PRP was added to bone grafting materials and the resulting bone putty was placed in the defect cavity. The postoperative result was considered satisfactory with a uniform filing of the defect by the bone-grafting material.<\/p>\n

The effectiveness of using autologous bone marrow cell concentrate to improve bone regeneration processes, both alone and in combination with osteoplastic materials, has been confirmed by many studies. The use of bone grafts and bone substitute in combination with bone marrow cell and\/or platelet-rich plasma reduces the degree of immune response, promotes osseointegration and bone remodeling processes, which expands the possibilities of using surgical methods for biological reconstruction of bone tissues. To stimulate bone regeneration, it is recommended to use activated platelet-rich plasma. The induction of PRP coagulation, with for exemple autologous serum as a source of activated thrombin, allow to create and maintain the necessary shape of the material and ensure gradual release of growth factors all along the bone healing process.<\/p>\n

Voroby<\/span><\/span><\/span><\/span><\/span>\u043e<\/span><\/span><\/span><\/span><\/span>v K., Skipenko T., Zagorodniy N., Smolentsev D., Zakirova A., Sevastianov V. Autologous regenerative stimulants for bone allograft implantation. Regenerative Medicine and Cell Technology. doi: 10.15825\/1995-1191-2020-4-133-139.<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/a><\/p>\n

Lychagin A, Lipina M, Garkavi A, Islaieh O, Timashev P, Ashmore K, Kon E. Intraosseous injections of platelet rich plasma for knee bone marrow lesions treatment: one year follow-up. Int Orthop. 2021 Feb;45(2):355-363. doi: 10.1007\/s00264-020-04546-5. Epub 2020 Apr 4. PMID: 32248264.<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/a><\/p>\n

Scaglione M, Fabbri L, Dell’Omo D, Gambini F, Guido G. Long bone nonunions treated with autologous concentrated bone marrow-derived cells combined with dried bone allograft. Musculoskelet Surg. 2014 Aug;98(2):101-6. doi: 10.1007\/s12306-013-0271-2. Epub 2013 May 23. PMID: 23700322.<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
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RegenLab<\/span><\/a>\u00ae<\/sup>\u00a0is a leading innovator of medical devices for the preparation of platelet rich plasma (PRP). RegenLab develops, provides expertly designed and patented medical devices for PRP preparations, CE certified by European Notify body, approved by most national agencies worldwide. <\/span><\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
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New Patents<\/span><\/h6>\n

For its Regenkit\u00ae<\/sup>\/RegenPRP\u00ae<\/sup> products (PRP alone technology), the United States Patent and Trademark Office (USPTO) has recently issued U.S. Patents No. 11,241,458 <\/b>directed to (i) several types of sterilized, vacuum-sealed, separator tubes (therapeutic and aesthetic use) for preparing PRP comprising an anticoagulant and a thixotropic gel and (ii) methods for preparing therapeutic PRP comprising centrifuging once such tubes.<\/span><\/p>\n

Further, in relation to its PRP-HA technologies, Regen Lab is also delighted to announce recently issued patents in Europe and Korea, respectively EP3223875B1<\/b> and KR102362722B1<\/b> directed to kits\/devices\/systems for the preparation of BMC\/PRP with hyaluronic acid comprising two containers \u2013 the first one containing an anticoagulant, a thixotropic gel and a biomaterial, and the second one containing another biomaterial \u2013 the biomaterials being selected from hyaluronic acid, chitosan and\/or silk protein, and further optional combinations with e.g. cell extracts and\/or coagulation activators.<\/p>\n

Regen Lab actively pursues patent protection and regulatory approval of its products so that physicians have peace of mind that they can offer continuous, consistent, safe and effective treatment for their patients without the fear of being restricted in their practice.<\/p>\n

More information on RegenLab patent<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
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These 3 books are intended for physicians who practice and conduct research in disciplines where PRP represents a therapeutic option as well as anyone seeking reliable and up-to-date information on this technology.<\/span><\/h6>\n
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Platelet-Rich Plasma (PRP) Standardization & Cell TherapyThis book<\/b> (178 pages, English) was written to help professionals involved in regenerative medicine to better understand PRP and cell therapies use. <\/span>Order it\u00a0<\/span><\/a><\/span><\/span>Standardized Platelet-Rich Plasma for Musculoskeletal Disorders<\/b> Based on 20 years of experience, this book (179 pages, English) was written to help professionals involved in the management of patients suffering from musculoskeletal disorders to better understand PRP and its combination with hyaluronic acid. <\/span>Order it<\/span><\/a><\/p>\n

RegenPRP\u00ae: Standardized Platelet Rich Plasma for Skin, Hair & Genitourinary Disorders\u00a0<\/b>Based on 20 years of experience, this book (211 pages, English) was written to help professionals involved in regenerative medicine for management of patients suffering from skin, hair and genitourinary disorders to better understand the use of PRP. <\/span>Order it<\/span><\/a><\/p>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n

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Live talks on specific therapeutic indications with international specialists<\/b>
\nThe Biobridge Foundation hosts a program of webinars, focused on various therapeutic areas within regenerative medicine, presented by international specialists. <\/span>Check out the full program<\/span><\/a><\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
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