{"id":12704,"date":"2022-02-11T15:17:04","date_gmt":"2022-02-11T14:17:04","guid":{"rendered":"https:\/\/library.biobridge-event.com\/knowledge\/?p=12704"},"modified":"2022-03-30T13:06:40","modified_gmt":"2022-03-30T12:06:40","slug":"newsletter-8-february-2022","status":"publish","type":"post","link":"https:\/\/library.biobridge-event.com\/knowledge\/2022\/02\/11\/newsletter-8-february-2022\/","title":{"rendered":"Newsletter #8 February 2022"},"content":{"rendered":"
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Each month, find new publications about regenerative medicine<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/td>\n

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Issue #8, February 2022<\/strong><\/span><\/span><\/h2>\n

Biobridge Foundation, Regenerative Medicine News<\/span><\/span><\/h4>\n

For once, this newsletter will not highlight recently published works but wishes to challenge the scientific community.<\/span><\/span><\/span><\/span><\/p>\n

Bruno BOEZENNEC, MD, Managing Editor<\/em><\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
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K. Bennell, l’arroseur arros\u00e9<\/i> with the Restore paper published in the JAMA<\/span><\/h6>\n

PRP in knee osteoarthritis (KOA) has developed substantially in recent years, which can be seen both in the scientific literature and in clinical practice. Experts agree that PRP can be proposed after failure of well-conducted oral and topic symptomatic treatments and appropriate physiotherapy. Clinicians consider \u00a0PRP as an effective treatment for symptomatic early or moderate KOA and that it might be used in severe forms of KOA, particularly in cases with\u00a0contraindications to surgery.<\/b><\/span><\/p>\n

The publication of the Restore study results in the November 23, issue of JAMA1<\/sup> has generated many comments and questions in the medical community.<\/p>\n

One of the issues raised is the lack of interim data on the primary clinical endpoint of knee pain assessed at 2 and 12 months by a numeric rating scale. This information is disturbing because in the Paterson et al. (2018)<\/i> article detailing the outline of the study it is clearly stated that pain intensity was, very logically, assessed at 2, 6, 9 and 12 months.<\/p>\n

In recent years, several meta-analyses have compared PRP with other KOA treatment modalities.<\/p>\n

Two level I meta-analysis compared PRP with placebo or hyaluronic acid.<\/p>\n

In a summary of meta-analysis, Chen et al. (2019)<\/i> concluded that for short-term follow-up (\u22641 year), intra-articular PRP injection is more effective in terms of pain relief and function improvement in the treatment of KOA patients than HA and placebo with the same safety3<\/sup>.<\/p>\n

Tan et al. (2021)<\/i> published recently in Arthroscopy a meta-analysis of 26 randomized controlled trials compared intra-articular injections of PRP with HA in KOA and concluded that PRP could significantly reduce pain and improve function4<\/sup>.<\/p>\n

The significant protocol deviation not reported in the publication has serious consequences, insofar as it could moderate the conclusions of the study and\u00a0must be clarified.<\/b><\/p>\n

1.\u00a0\u00a0 \u00a0<\/span>Bennell KL, Paterson KL, Metcalf BR, et al. Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis: The RESTORE Randomized Clinical Trial. JAMA. 2021;326(20):2021\u20132030<\/span><\/a>
\n2.\u00a0\u00a0 \u00a0<\/span>Paterson, K.L., Hunter, D.J., Metcalf, B.R. et al. Efficacy of intra-articular injections of platelet-rich plasma as a symptom- and disease-modifying treatment for knee osteoarthritis – the RESTORE trial protocol. BMC Musculoskelet Disord 19, 272 (2018).<\/span><\/a>
\n3.\u00a0\u00a0 <\/span>\u00a0Chen, P., Huang, L., Ma, Y. et al. Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses. J Orthop Surg Res 14, 385 (2019).<\/span><\/a>
\n4.\u00a0\u00a0 \u00a0<\/span>Tan J, Chen H, Zhao L, Huang W. Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-analysis of 26 Randomized Controlled Trials. Arthroscopy. 2021 Jan;37(1):309-325<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
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\"Regenlab.com\"<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n
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RegenLab<\/span><\/a>\u00ae<\/sup>\u00a0is a leading innovator of medical devices for the preparation of platelet rich plasma (PRP). RegenLab develops, provides expertly designed and patented medical devices for PRP preparations, CE certified by European Notify body, approved by most national agencies worldwide. <\/span><\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
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These 3 books are intended for physicians who practice and conduct research in disciplines where PRP represents a therapeutic option as well as anyone seeking reliable and up-to-date information on this technology.<\/span><\/h6>\n
Platelet-Rich Plasma (PRP) Standardization & Cell TherapyThis book<\/b> (178 pages, English) was written to help professionals involved in regenerative medicine to better understand PRP and cell therapies use. <\/span>Order it\u00a0<\/span><\/a><\/span><\/span>Standardized Platelet-Rich Plasma for Musculoskeletal Disorders<\/b> Based on 20 years of experience, this book (179 pages, English) was written to help professionals involved in the management of patients suffering from musculoskeletal disorders to better understand PRP and its combination with hyaluronic acid. <\/span>Order it<\/span><\/a><\/p>\n

RegenPRP\u00ae: Standardized Platelet Rich Plasma for Skin, Hair & Genitourinary Disorders\u00a0<\/b>Based on 20 years of experience, this book (211 pages, English) was written to help professionals involved in regenerative medicine for management of patients suffering from skin, hair and genitourinary disorders to better understand the use of PRP. <\/span>Order it<\/span><\/a><\/p>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n

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Live talks on specific therapeutic indications with international specialists<\/b>
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